Putri, Jessica and Sutanto, Hery and Kartawiria, Irvan S. (2012) Development of Eye Drops from Natural Extract of Butterfly Pea Petal Extract as the Active Pharmaceutical Ingredient. Bachelor thesis, Swiss German University.
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Abstract
Empirically the blue water extract from butterfly pea petal has been used as a traditional eye drops to relieve eye irritations such as eye redness and dry eyes. The purpose of this research was to develop the butterfly pea petal extract as the active ingredients for eye drops product. The sterility, stability, and compatibility of the extract as the active ingredients for eye drops product were examined. The sterility of the extract was achieved by doing two techniques; autoclaving the extract and by pasteurization. The stability of the extract was examined during 14 days storage period. The compatibility was examined by adding the extract to eye drops excipients, such as commercial eye drops solution, NaCl + Na2EDTA solution, and NaCl solution. Autoclaving at 121 oC for 15 minutes and pasteurization at 80-90 oC for 30 minutes were effective to sterilize the extract and were able to preserve the bioactive compound that act as the antimicrobial. The butterfly pea petal was compatible with NaCl solution. The MIC for Escherichia coli and Staphylococcus aureus were 75µl/ml and 130µl/ml, respectively.
| Item Type: | Thesis (Bachelor) |
|---|---|
| Uncontrolled Keywords: | Clitoria Ternatea L; Eye Drops; Minimum Inhibitory Concentration (MIC) |
| Subjects: | R Medicine > RE Ophthalmology > RE51 Eye--Care and hygiene R Medicine > RS Pharmacy and materia medica > RS160 Plant extracts |
| Divisions: | Faculty of Life Sciences and Technology > Department of Pharmaceutical Engineering |
| Depositing User: | Astuti Kusumaningrum |
| Date Deposited: | 26 Mar 2021 04:03 |
| Last Modified: | 26 Mar 2021 04:03 |
| URI: | http://repository.sgu.ac.id/id/eprint/1183 |
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