Pangestu, Stefanus and Gunawan, Paulus and Pandjaitan, Maruli (2012) The Creation of Bromelain Lozenges From Pineapple (Ananas Comosus). Bachelor thesis, Swiss German University.

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Abstract

Pineapple has a proteolytic enzyme called bromelain. Recent discovery, bromelain has the potential to treat HIV/AIDS patients. The problem is that pineapple has very short shelf life and very easy to spoil. Bromelain in table form has relatively longer shelf life and can be consume anytime and anywhere. In this research, the bromelain tablet was produced with wet granulation, drying process and tablet compression. Another problem with drying is bromelain is heat sensitive and can lose activity so excipients such as binder, filler, disintegrant, lubricant and preservative was added at the granulation process before the drying process. The addition of excipients can protect the bromelain but at the same time, it reduce the amount of active pharmaceutical ingredient by diluting the bromelain with excepients by several times. The best possible formulation needed to be discovered in order to make a good tablet and at the same time it protect the bromelain enzyme activity in the tabler form.

Item Type:	Thesis (Bachelor)
Uncontrolled Keywords:	Bromelain Extraction; Specific Activity Preservation; Tabletting Process; Hardness Testing
Subjects:	R Medicine > RS Pharmacy and materia medica > RS192 Pharmaceutical technology S Agriculture > SB Plant culture > SB375 Pineapple
Divisions:	Faculty of Life Sciences and Technology > Department of Pharmaceutical Engineering
Depositing User:	Astuti Kusumaningrum
Date Deposited:	26 Mar 2021 04:06
Last Modified:	26 Mar 2021 04:06
URI:	http://repository.sgu.ac.id/id/eprint/1216

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