Kho, Cindy and Gunawan, Paulus and Kartawiria, Irvan S. (2014) Development of Particle Size Determination Model in High Shear Mixing Wet Granulation. Bachelor thesis, Swiss German University.

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Abstract

Rapid growth rate in high shear mixing wet granulation demands better understanding of its growth kinetics in order to monitor and modify the process. This research aims to report the significance of several process variables in correlation with particle growth. Growth kinetic model was expected to be found and provide implications to granulation technology. Initial particle size, impeller speed and chopper speed was set at two levels of treatment in a binary mixture of lactose and water. The mean size of granules obtained was analyzed through laser diffraction and grid counting method. It was observed that smaller initial size produced larger granules (42.438 µm into 277.514 µm–5.5038 mm vs. 83.712 µm into 152.513 µm–4.5187 mm). Impeller speed showed different trends in correlation with energy threshold for growth (e.g. 220 rpm into 382.487 µm and 110 rpm into 446.035 µm vs. 220 rpm into 348.222 µm and 110 rpm into 152.513 µm). Higher chopper speed was effective in reducing size (e.g. 1500 rpm into 4.4861 mm vs. 750 rpm into 5.4225 mm). Particle growth was steady for granules below 2 mm, while granules above 2 mm showed relatively unsteady growth. Granule growth was extremely fast and granulation is not governed by chemical properties.

Item Type:	Thesis (Bachelor)
Uncontrolled Keywords:	Granulation; High shear; Growth; Binary Mixture; End Point
Subjects:	R Medicine > RS Pharmacy and materia medica > RS192 Pharmaceutical technology
Divisions:	Faculty of Life Sciences and Technology > Department of Pharmaceutical Engineering
Depositing User:	Astuti Kusumaningrum
Date Deposited:	30 Dec 2021 16:38
Last Modified:	30 Dec 2021 16:38
URI:	http://repository.sgu.ac.id/id/eprint/1244

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