Jonathan, Kevin and Pandjaitan, Maruli and Audah, Kholis Abdurachim (2016) Cytotoxicity of Annona Muricata Extract with Addition of Allium Sativa and Curcuma Mangga for Cancer Treatment. Bachelor thesis, Swiss German University.

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Abstract

Soursop leaves (Annona muricata) are composed of a lot of alkaloid chemical constituents such as Annonaceous acetogenins, which are believed to have cytotoxic properties against tumor cell lines. Garlic (Allium sativa) and white turmeric (Curcuma mangga), are also believed to have those properties of inhibiting the proliferation of cancer cells, besides being used as a natural flavor enhancer. The general objective of this research was to prove that the extract of Soursop leaves combined with Garlic and White turmeric is effective to inhibit the growth of cancer cell lines. They will be extracted using ethanol, and later will be distilled to remove all the alcohol remained in the extract, because it was meant to be consumed. MTT assay was done in order to obtain the inhibition of cancer cell activity of the extract. NADH oxidation enzyme inhibition was performed to obtain the optmal concentration, and BSLT was conducted to show the bioactivity of the extract. The extract showed an inhibition result of 59.78% while the LC50 obtain from the extract using BSLT was 93.73 ppm.

Item Type:	Thesis (Bachelor)
Uncontrolled Keywords:	Soursop leaves; NADH Inhibition Activity; Allium Sativa; Curcuma Mangga; Anti-Cancer Activity; MTT, Lethal Concentration.
Subjects:	R Medicine > R Medicine (General) > R856 Biomedical engineering R Medicine > RM Therapeutics. Pharmacology > RM666 Herbs--Therapeutic use
Divisions:	Faculty of Life Sciences and Technology > Department of Biomedical Engineering
Depositing User:	Atroridho Rizky
Date Deposited:	10 Nov 2020 13:55
Last Modified:	10 Nov 2020 13:57
URI:	http://repository.sgu.ac.id/id/eprint/1387

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