Yusuf, Nur Ratih Kusumaningayu and Legowo, Evita H. and Sutanto, Hery (2015) Improvement in the Extraction of Squalene from Palm Fatty Acid Distillate. Bachelor thesis, Swiss German University.

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Abstract

Squalene is a natural antioxidant extracted mostly from shark’s liver. Due to the main source extinction, an alternative source of squalene has been studied and one of the sources can be obtained from edible vegetable oils including palm oil. Large amounts of palm fatty acid distillate (PFAD) waste from palm oil refinery contain squalene and other bioactive compounds such as vitamin E, and phytosterols. Therefore, a simple methodology to utilize PFAD waste as source of squalene was developed by saponification process continued with liquid liquid extraction using different non- polar solvents: n-heptane, chloroform and dichloromethane. The crude squalene yield obtained from n-heptane, chloroform and dichloromethane extracts were 81.86%, 22.16% and 75.35% respectively. The crude extract still contained large amount of free fatty acids impurities which influenced the squalene content obtained. The squalene content of n-heptane, chloroform, and dichloromehane extracts were 0.97%, 0.67% and 4.55 respectively. The antioxidant activity was carried out using 2,2- diphenyl-1-picrylhydrazyl (DPPH) Radical-Scavenging Assay. Crude squalene extract from dichloromethane showed the highest activity of 0.0073 mg DPPH/mg Extract.

Item Type:	Thesis (Bachelor)
Uncontrolled Keywords:	Squalene; Saponification; Liquid Liquid Extraction; Non-Polar Solvents; Palm Oil; Palm Fatty Acid Distillate; Antioxidant Activity.
Subjects:	R Medicine > RS Pharmacy and materia medica R Medicine > RS Pharmacy and materia medica > RS160 Plant extracts R Medicine > RS Pharmacy and materia medica > RS192 Pharmaceutical technology T Technology > TP Chemical technology > TP684 Palm oil
Divisions:	Faculty of Life Sciences and Technology > Department of Pharmaceutical Engineering
Depositing User:	Atroridho Rizky
Date Deposited:	18 Dec 2020 16:33
Last Modified:	18 Dec 2020 16:33
URI:	http://repository.sgu.ac.id/id/eprint/1633

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