Darnadi, Jason and Arsianti, Ade and Audah, Kholis Abdurachim (2019) Evaluation Of mangrove extract Xylocarpus Granatum as antioxidant and anticancer potential. Bachelor thesis, Swiss German University.

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Abstract

Many phytochemical compounds found in nature were classified as bioactive. The phytochemicals found in one species could differ from the same species in a different ethnogeographic region due to environmental factors. Local species of mangrove plant Xylocarpus granatum extracted by ethyl acetate was tested for anticancer and antioxidant activity to be used as a potential anticancer drug. Leaf extract of X. granatum was assayed with DPPH to determine antioxidant activity caused by phytochemicals found in extract and BLST as toxicity test. Extracts were assayed with MTT cytotoxicity assay using cancer cells HT-29, T47D, HeLa, and stem cell hADSC. X. granatum leaf extract was found to contain flavonoids as the majority phenolic compounds, which was determined to have intermediate antioxidant activity and nontoxic to brine shrimps. Inhibition was observed only in all cancer cells and most effective against HT-29, meaning that the extract had anticancer activity and was not toxic but life supporting towards normal cells. Stability test of the extract was also conducted by comparing results of phenolic content and anticancer activity. Further research on anticancer activity mechanism is needed to determine whether the extract is suitable as a candidate for anticancer drug.

Item Type:	Thesis (Bachelor)
Uncontrolled Keywords:	Natural Products ; Stability ; Xylocarpus granatum
Subjects:	R Medicine > R Medicine (General) T Technology > TA Engineering (General). Civil engineering (General)
Divisions:	Faculty of Life Sciences and Technology > Department of Biomedical Engineering
Depositing User:	Maria Lamury
Date Deposited:	21 Apr 2020 15:58
Last Modified:	10 Feb 2022 03:50
URI:	http://repository.sgu.ac.id/id/eprint/20

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