Audah, Kholis Abdurachim (2021) Evaluation of Indonesian Mangrove Xylocarpus Granatum Leaves Ethyl Acetate Extract as Potential Anticancer Drug. Scientific Reports, 11 (6080). pp. 1-18. ISSN 20452322
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Evaluation of Indonesian Mangrove X. granatum-Scientific Reports volume 11, Article number 6080 (2021).pdf Download (1MB) | Preview |
Abstract
Local Xylocarpus granatum leaves were extracted by ethyl acetate solvent and characterized by TLC fingerprinting and 2D 1H NMR spectroscopy to contain phenolic compounds as well as several organic and amino acids as metabolic byproducts, such as succinic acid and acetic acid. Traces of flavonoids and other non-categorized phenolic compounds exhibited intermediate antioxidant activity (antioxidant IC50 84.93 ppm) as well as anticancer activity against HeLa, T47D, and HT-29 cell lines; which the latter being most effective against HT-29 with Fraction 5 contained the strongest activity (anticancer IC50 23.12 ppm). Extracts also behaved as a natural growth factor and nonlethal towards brine shrimps as well as human adipose-derived stem cell hADSC due to antioxidative properties. A stability test was performed to examine how storage conditions factored in bioactivity and phytochemical structure. Extracts were compared with several studies about X. granatum leaves extracts to evaluate how ethnogeography and ecosystem factored on biologically active compounds. Further research on anticancer or antioxidant mechanism on cancer cells is needed to determine whether the extract is suitable as a candidate for an anticancer drug.
| Item Type: | Article |
|---|---|
| Subjects: | R Medicine > R Medicine (General) R Medicine > R Medicine (General) > R856 Biomedical engineering |
| Divisions: | Faculty of Life Sciences and Technology > Department of Biomedical Engineering |
| Depositing User: | Kholis Audah Abdurachim |
| Date Deposited: | 10 Apr 2023 01:23 |
| Last Modified: | 14 Apr 2023 06:21 |
| URI: | http://repository.sgu.ac.id/id/eprint/2458 |
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