Audah, Kholis Abdurachim Evaluation of the Ethyl Acetate Extract of the Roots of Avicennia marina as Potential Anticancer Drug. Atlantis Press.

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Abstract

In this modern age cancer is still a prevalent disease. Even with advancements of technology, current treatments for cancer still have various side-effects that sometimes create more harm to the patient. A complete solution for cancer is still not found yet. Recently, mangroves were shown to be promising sources of new drugs. The species Avicennia marina was suggested to be anti-cancerous, thus it could be a potential anticancer drug. This study was conducted to evaluate the viability of A. marina root ethyl acetate extract as a possible anticancer drug, and to determine whether its anticancer mechanisms are by counteracting the reactive oxygen species as an antioxidant. The extract was subjected to total phenolic and flavonoid content tests, to determine the bioactive compounds, which are thought to be directly related to antioxidant activities. The DPPH method was used to evaluate the antioxidant activity of the extract. Brine shrimp (Artemia salina) was subjected to the extract to determine its toxicity, and determined its anticancer properties against cancer cell lines HT29 (colon), HeLa (cervix) and T47D (breast) by MTT Assay. Results showed that the extract has moderate amounts of phenolic and flavonoids, moderate antioxidant activity, not toxic to normal cells but toxic towards cancer cells.

Item Type:	Article
Subjects:	R Medicine > R Medicine (General) R Medicine > RS Pharmacy and materia medica R Medicine > RS Pharmacy and materia medica > RS160 Plant extracts
Divisions:	Faculty of Life Sciences and Technology > Department of Biomedical Engineering
Depositing User:	Kholis Audah Abdurachim
Date Deposited:	10 Apr 2023 01:41
Last Modified:	10 Apr 2023 01:41
URI:	http://repository.sgu.ac.id/id/eprint/2473

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