Audah, Kholis Abdurachim The Antimicrobial Effectiveness of Novel Non-Resistant THESS for Carpet Application. THE ANTIMICROBIAL EFFECTIVENESS OF NOVEL NON-RESISTANT THESS FOR CARPET APPLICATION.
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Abstract
Antimicrobial additives are used in numbers of products for their availability to prevent product degradation and to provide hygienic properties. These additives are also used for carpet application in controlling biocontaminants in indoor environments. Bacteria contamination on the carpet has been recognized as one of the most common cause of diseases, such as Norovirus infection, Campylobacteriosis, Kawasaki Syndrome and many others. The aim of this study was to analyze two of the pertinent test methods to analyze the effectiveness of Tetra Hydroxyl Ethyl dibiSulphite-2-Sodium (THESS) for carpet application against Escherichia coli and Staphylococcus aureus. THESS is a novel class of antibacterial agent with a unique killing mechanism that works from outside of the bacterial cell. The unique feature of THESS as a sulphide chelating agent is the very strong bond formed with the target ligands. This bond is the main key of the bacterial peptidoglycan porosity enlargement which caused lysis and lead to bacterial cell death. The macrodilution technique was conducted for determining the minimal inhibitory concentration (MIC) of THESS. Antimicrobial effectiveness test was conducted by two methods, modified AATCC 174 test I and OECD guideline which was harmonized to ISO 22196. Both are well known standard methods for measuring the qualitative and quantitative inhibition of microbial growth on carpet. The effectiveness of the two methods was then analyzed. MIC of THESS was determined at 0.5% w/v solution against the two tested bacteria. In conclusions, the AATCC 174 test I did not show any inhibition zone in both THESS- carpet and untreated carpet, while the OECD guideline showed the effectiveness of THESS-carpet against E. coli and S. aureus with the reduction of colony numbers 95.86% and 95.07%, respectively. This result suggested that application of THESS as antimicrobial in carpet is considered effective according to the standard of minimum 90% reduction of bacterial colonies.
| Item Type: | Article |
|---|---|
| Subjects: | Q Science > QR Microbiology > QR177 Multidrug resistance |
| Divisions: | Faculty of Life Sciences and Technology > Department of Biomedical Engineering |
| Depositing User: | Kholis Audah Abdurachim |
| Date Deposited: | 10 Apr 2023 01:40 |
| Last Modified: | 14 Apr 2023 03:11 |
| URI: | http://repository.sgu.ac.id/id/eprint/2479 |
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