Peptidoglycan Cell Membrane as Antibacterial Target

Audah, Kholis Abdurachim Peptidoglycan Cell Membrane as Antibacterial Target. In: SEMINAR NASIONAL XX PERHIMPUNAN BIOKIMIA DAN BIOLOGI MOLEKULER INDONESIA (PBBMI), 16-18 December 2016, FK UNILA.

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Antibiotic resistant bacterial infections are among of the major health problems that promote many studies from multidisciplinaryfields. Globally, 480,000 people isinfectedby resistant TB every year and it can not be solved. The results of the study of antibacterial resistance in 2000-2004, Methicillin Resistant Staphylococcus aureus (MRSA) and a bacteria Extended Spectrum Beta lactamases (ESBL) are identified in the Hospital dr. Soetomo and dr. Kariadi Semarang. Some types of bacteria become resistant due to several factors. In general, antibioticsworked through penetrating cell membranes and disrupting the process of peptidoglycan biosynthesis of bacterial cell membrane constituent (antimitotic). However, this mechanism proved to trigger bacterial resistance. The bacteria can learn the mechanisms and increase the resistancegradually. Therefore, the appropriate approachs to eliminate bacterial resistance is very important and should be a priority in the health field. A more appropriate approach is to use chemical or natural compounds that damage the cell membrane directly from the outside of the bacterial cell, so the chances of resistance becoming smaller. This type of work specific antibacterial bind to peptidoglycan cell membranes, resulting in increased porosity of cell membranes and cause cell lysis or death. This article contains a discussion of the mechanism of action of antibiotics, development of resistance in bacteria and how these resistant bacteria can spread. Ultimately, this understanding can encourage the development of antibacterial synthesis much more effective and safe in terms of bacterial resistance.

Item Type: Conference or Workshop Item (Paper)
Subjects: Q Science > QR Microbiology
Q Science > QR Microbiology > QR177 Multidrug resistance
R Medicine > R Medicine (General)
R Medicine > R Medicine (General) > R856 Biomedical engineering
Divisions: Faculty of Life Sciences and Technology > Department of Biomedical Engineering
Depositing User: Kholis Audah Abdurachim
Date Deposited: 10 Apr 2023 01:40
Last Modified: 14 Apr 2023 04:07

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