Audah, Kholis Abdurachim Methods Development for Mangrove Extraction towards Standardization of Indonesian Extract Library. Methods Development for Mangrove Extraction towards Standardization of Indonesian Extract Library. (Unpublished)
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Abstract
Natural resources, plants in particular, have been utilized by human for different purposes including as medicines. Drug discovery processes can be accelerated through a large collection of extracts in numbers, quality and quantity. By virtue of its vast numbers of biodiversity, developing a large collection of extracts (extract library) for drug discovery in Indonesia is very plausible thing to do. Due to the variations of chemical constituents of a plant, a reproducible method of extraction and profiling should be developed. The aim of this study is to develop some methods for extraction and profiling of mangrove plants. The methods will be used as the basis for development for Indonesian extract library especially for drug discovery and cosmetics. In this study, mangrove plants had been chosen due to their availability and potential as medicines. Several factors that could possibly determine chemical constituents were taken into consideration. These include but not limited to location, date and time, packaging, storage, species identification, solvents, extraction method and fingerprint profiling. Stability testing should also be conducted for mid and longterm storage. Extraction methods used in this study were maceration and ultrasonic assisted extraction by employing various solvents representing different polarity such as water, alcohol, ethyl acetate and hexane. Thin layer chromatography method was used for fingerprint profiling. In the future, implementation of barcoding system and integration of all data into a comprehensive information system is necessary. This can be utilized as a window of the Indonesian extract library as a whole.
| Item Type: | Article |
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| Subjects: | R Medicine > RS Pharmacy and materia medica R Medicine > RS Pharmacy and materia medica > RS160 Plant extracts |
| Divisions: | Faculty of Life Sciences and Technology > Department of Biomedical Engineering |
| Depositing User: | Kholis Audah Abdurachim |
| Date Deposited: | 12 Apr 2023 02:45 |
| Last Modified: | 14 Apr 2023 02:06 |
| URI: | http://repository.sgu.ac.id/id/eprint/2532 |
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