Santoso, Filiana and Soedarma, Chelsea and Adiyoga, G. Herdiazto and Puteri, Maria Dewi P. T. Gunawan and Sutanto, Hery (2016) Alpha-Glucosidase Inhibitory Effect of Methanolic Extracts from Indonesian Plants. In: 2nd international conference on sustainable global agriculture and food, 9-10 August 2016, Semarang, Indonesia.
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Abstract
Alpha-glucosidase inhibitors (AGIs) are oral anti-diabetic drugs used for type-2 diabetes treatment by retarding the carbohydrate digestion. There are numerous natural products with AGI action, however, only limited number of Indonesian plants have been studied for their AGIs potency. In this research, 57 samples of plants naturally grown in Indonesia were tested in vitro for their AGIs activities. Some of them are traditionally utilized for diabetes treatment. The study showed that the methanolic extracts of gambir fruit (Uncaria gambir), banana leaf (Musa paradisiaca), lemongrass stem (Cymbopogon citratus), bitter gourd fruit (Momordica charantia), and onion bulb (Allium cepa L.) exhibited the highest AGIs activities at 0.02 g/ml concentration. The gradient extraction using n-hexane, ethyl acetate, and butanol resulted in ethyl acetate and butanol fractions showing high AGIs activity, indicating that the AGIs activities in these five samples were influenced by the existence of semi-polar to polar compounds. Antioxidant activity, total phenolic and flavonoid contents were also evaluated. Gambir fruit exhibited the highest antioxidant activity followed by onion bulb, banana leaf, bitter gourd fruit, and lemongrass stem with IC50 of 101.75 ppm, 1,963.57 ppm, 2,377.64 ppm, 5,859.14 ppm and 5,910.14 ppm, respectively. Total phenolic and flavonoid analysis showed that the activity of gambir fruit was supported by the high content of phenolic (77.56 mg GAE/g), while the onion bulb exhibited the highest flavonoid content (8.94 mg QE/g). Positive correlation of antioxidant activity and total phenolic content with AGIs was found, however, there was no correlation between AGIs and total flavonoid content.
| Item Type: | Conference or Workshop Item (Paper) |
|---|---|
| Divisions: | Faculty of Life Sciences and Technology |
| Depositing User: | Library SGU |
| Date Deposited: | 12 Apr 2023 03:52 |
| Last Modified: | 12 Apr 2023 05:58 |
| URI: | http://repository.sgu.ac.id/id/eprint/2536 |
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