Adhitama, Imelda and Santoso, Filiana and Pandiangan, Febbyandi (2019) Evaluation of antioxidant, alpha-glucosidase inhibitory and antimicrobial activities of extracts of peel, seed fruit flesh and endocarp of pometia pinnata. Bachelor thesis, Swiss German University.

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Abstract

The research investigated the potential activities of the peel, seed, fruit flesh and endocarp of Pometia pinnata as natural sources for antioxidant, alpha-glucosidase inhibitor and antimicrobial agents. The total phenolic and flavonoid contents of the extracts were also determined and correlated to the activities. Three solvents with different polarity (hexane, ethyl acetate and methanol) were applied in the gradient extraction of the fruit. The endocarp methanolic extract exhibited the strongest antioxidant activity against DPPH radical compounds (IC50 0.27 ?g/ml), even significantly stronger than commercial antioxidant, L-Ascorbic acid (IC50 8.10 ?g/ml). The extract was also found to have the highest total phenolic and flavonoid contents. In addition, it revealed the highest alpha-glucosidase inhibitory activity against sucrose and maltose hydrolysis by rat intestinal enzyme, though it was significantly lower than the commercial inhibitor acarbose. Furthermore, the flesh methanolic extract also showed similarly high activity in maltase inhibition. All crude extracts showed bacteriostatic capacity, but the MIC from broth macrodilution against Staphylococcus aureus and Escherichia coli were only detected in the endocarp methanolic extract with both MIC 500 ?g/ml. In conclusion, methanol was found to capable of extracting bioactive compounds contributing as antioxidant, AGI and antimicrobial agents. The endocarp methanolic extracts particularly showed the highest potency in all activities, which was discovered in this study for the first time.

Item Type:	Thesis (Bachelor)
Uncontrolled Keywords:	Antioxidant ; Antimicrobial ; Alpha-glucosidase
Subjects:	R Medicine > R Medicine (General)
Divisions:	Faculty of Life Sciences and Technology > Department of Food Technology
Depositing User:	Maria Lamury
Date Deposited:	25 Apr 2020 04:13
Last Modified:	25 Apr 2020 04:13
URI:	http://repository.sgu.ac.id/id/eprint/28

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