Dewi, Putri Astari and Legowo, Evita H. and Sutanto, Hery (2017) Improvement In The Extraction Of Shikimic Acid From Palm Oil Mill Effluent. Bachelor thesis, Swiss German University.

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Abstract

Shikimic acid is a substantial compound that acts as a precursor for the synthesis of the oseltamivir drug (Tamiflu) that used in the treat influenza viruses type A and B including H5N1or avian flu. The objective of this research is to improve shikimic acid extraction from Palm Oil Mill Effluent (POME). This research was conducted with liquid-liquid extraction of the organic compound with two solvents: Dichloromethane (DCM) and Tetrachloroethylene (TCE). There are two parameters used in the experiments which are extraction solvent ratio and mixing time. The extraction ratio 60:40 with mixing time of 15 minutes has the highest yield in both extraction solvent which are 8.897% and 6.763%. The extraction followed with analysis method using Fourier Transform Infrared Spectroscopy (FTIR), Thin Layer Chromatography (TLC), and Gas Chromatography (GC). The IR spectrum between the shikimic acid standard and samples extracted with DCM and TCE shows similar pattern shape. The TLC analysis also resulted in similar Rf between the standard and the samples. The GC chromatogram shows the similar retention time between the shikimic acid standard and the sample. Moreover, some impurities were visible in all the analysis data including FTIR, TCL, and GC. Most of the impurities are saturated fatty acids.

Item Type:	Thesis (Bachelor)
Uncontrolled Keywords:	Shikimic Acid; Liquid Liquid Extraction; Crude Palm Oil; Palm Oil Mill Effluent; Gas Chromatography
Subjects:	Q Science > QD Chemistry > QD305 Fatty acids in human nutrition R Medicine > RS Pharmacy and materia medica > RS160 Plant extracts S Agriculture > SB Plant culture > SB299 Palm Oil
Divisions:	Faculty of Life Sciences and Technology > Department of Pharmaceutical Engineering
Depositing User:	Astuti Kusumaningrum
Date Deposited:	18 May 2020 01:43
Last Modified:	18 May 2020 01:43
URI:	http://repository.sgu.ac.id/id/eprint/465

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