MOntolalu, Vimothy Daniel and Legowo, Evita H. and Sutanto, Hery (2018) Optimization Of Pre-Treatment Process In Shikimic Acid Extraction From Palm Oil Mill Effluent (POME). Bachelor thesis, Swiss German University.

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Abstract

The global pandemic spread of influenza like bird flu and swine flu are forcing a bigger production of anti-influenza drug called Oseltamivir phosphate. The drug is made by synthesizing a compound named shikimic acid. Although the demand of the drug increases, the source of shikimic acid material is limited. Meanwhile, palm oil mill effluent (POME), a waste generated from palm oil industry is provenly rich in phytonutrients. This research aims to improve the shikimic extraction process from palm oil mill effluent by pre-treating the POME. Three pre-treatments were done on the POME which are solvent-extraction method, sedimentation method, and combination of solvent-extraction and sedimentation method. Sedimentation used the centrifugal principle and solvent-extraction used n-hexane as the solvent. Detection of shikimic acid was done using TLC method and FT-IR instrument, while HPLC was used to measure the amount of shikimic acid extracted. Yield of shikimic acid obtained after solvent-extraction pre-treatment (0.0795%) was better than the sedimentation pre-treatment (0.015%). Also, the solvent-extraction pre-treatment was more efficient (87.51%) than sedimentation pre-treatment (68.15%) in removing oil and grease. However, the best result was produced from the combination of both pretreatments.

Item Type:	Thesis (Bachelor)
Uncontrolled Keywords:	Shikimic Acid; Palm Oil Mill Effluent; HPLC; FT-IR; TLC
Subjects:	R Medicine > RS Pharmacy and materia medica > RS160 Plant extracts R Medicine > RS Pharmacy and materia medica > RS192 Pharmaceutical technology S Agriculture > SB Plant culture > SB299 Palm Oil
Divisions:	Faculty of Life Sciences and Technology > Department of Pharmaceutical Engineering
Depositing User:	Astuti Kusumaningrum
Date Deposited:	25 Sep 2020 02:18
Last Modified:	25 Sep 2020 02:18
URI:	http://repository.sgu.ac.id/id/eprint/858

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