Soedarma, Chelsea and Santoso, Filiana and Puteri, Maria Dewi P. T. Gunawan (2015) Isolation of Alpha Glucosidase Inhibitors from Indonesian Medicinal Plants. Bachelor thesis, Swiss German University.

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Abstract

Alpha-glucosidase inhibitors are oral anti-diabetic drugs which are used for diabetes treatment by retarding the carbohydrate digestion. In this research, 57 samples which mostly traditionally utilized for diabetes treatment and other medicinal treatments have been evaluated in vitro for its alpha-glucosidase inhibition activity. Among those plants, the methanol extract of Uncaria gambir, Musa paradisiaca, Momordica charantia and Allium cepa showed the high inhibitory activity with inhibition activity above 75%. Antioxidant activity analysis of the five best samples showed positif correlation with AGIs.Uncaria gambir showed highest inhibitory among five samples (100%, 0.02 g/ml).Therefore, it was further extracted with n-hexane, ethyl acetate, and butanol which displayed 24.18%, 71.73% and 55.29% inhibition activity respectively. Gambir in ethyl acetate extract was further fractionated using open column (silica gel, 30 x 500 mm) using hexane and ethyl acetate gradient eluent, resulting into 2 fractions (UGE-A and UGE-B). Further fractionation using preparative TLC resulted in three spots.The spots were further analysed using LC- MS/MS.

Item Type:	Thesis (Bachelor)
Uncontrolled Keywords:	Diabetes; Alpha-glucosidase Inhibitors; Antioxidant; Herbal; Gambir.
Subjects:	R Medicine > RM Therapeutics. Pharmacology > RM666 Herbs--Therapeutic use T Technology > TP Chemical technology > TP368 Food processing and manufacture
Divisions:	Faculty of Life Sciences and Technology > Department of Food Technology
Depositing User:	Atroridho Rizky
Date Deposited:	18 Dec 2020 16:26
Last Modified:	18 Dec 2020 16:26
URI:	http://repository.sgu.ac.id/id/eprint/1606

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