Krisna, Yola and Sutanto, Hery and Anita, Yulia (2015) Synthesis of Paracetamol Derivatives Using the Peroxidase Enzyme from Cauliflower. Bachelor thesis, Swiss German University.

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Abstract

Paracetamol or acetaminophen is classified as a mild analgesic and commonly used as an active pharmaceutical ingredient as a pain reliever and fever reducer and other minor aches and pains. Unfortunately, a little overdose of paracetamol may cause hepatoxocity or liver injury which lead to liver failure, liver transplant, or death. Reduction of paracetamol by cytochrome P-450 enzymes in the liver cells are produce NAPQI (N-acetyl-p-benzoquinone imine), a toxic metabolite that may cause a liver tissue injury. To prevent an oxidation of paracetamol, a dimer of paracetamol was synthesize to protect paracetamol from being oxidized. An enzymatic oxidative coupling synthesis reaction may produce several possible paracetamol derivatives products besides the dimeric compound as our main interest. Peroxidase enzyme as a catalyst was extracted from cauliflower, part of Brassicaceae family. A cation radical compound as the product of the reaction between peroxidase enzyme and hydrogen peroxide, initiates the dimerization of paracetamol through termination of the radicals. Based on the antioxidant activity assay using DPPH method, the antioxdidant activity of dimer of paracetamol is higher than paracetamol.

Item Type:	Thesis (Bachelor)
Uncontrolled Keywords:	Paracetamol; Synthesis Reaction; Dimerization; Dimer Of Paracetamol; Peroxidase Enzyme; Antioxidant Activity; Cauliflower.
Subjects:	R Medicine > RM Therapeutics. Pharmacology R Medicine > RM Therapeutics. Pharmacology > RM666 Herbs--Therapeutic use R Medicine > RS Pharmacy and materia medica > RS192 Pharmaceutical technology
Divisions:	Faculty of Life Sciences and Technology > Department of Pharmaceutical Engineering
Depositing User:	Atroridho Rizky
Date Deposited:	18 Dec 2020 16:35
Last Modified:	18 Dec 2020 16:35
URI:	http://repository.sgu.ac.id/id/eprint/1634

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