Teji, Stevan and Puteri, Maria Dewi P. T. Gunawan and Kato, Eisuke (2019) Analysis of Alpha-Glucosidase Inhibitor Activity in Wild Stenochlaena Palustris from Kalimantan Origin. Bachelor thesis, Swiss German University.

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Abstract

S. palustris is a fern commonly occurs in Malaysia, Indonesia, India, and some other Asian countries, the fronds of the fern are consumed for dietary and medicinal purposes. S. palustris was mentioned as a potent alpha-glucosidase inhibitor source on par with the current commercial synthetic alpha-glucosidase inhibitors. Considering the quality of herbal medicines is determined by which cultivation technologies were applied to and the ecological conditions in which the plants grow. With a thoroughly controlled excavation process, the effect of the pre-treatments of sample can be analysed on whether or not it affects the biochemical activity. This study found that S. palustris from Kalimantan origin have active glucosidase inhibitory activity on sucrase and maltase also anti-amylase activity. Methanol (50.15% maltase inhibition at 10 mg/ml, 65.87% Alpha-amylase inhibition at 1 mg/ml) and 50% aq. methanol (54.84% maltase inhibition at 10 mg/ml, 61.34 ± 0.45 % alpha-amylase inhibition at 1 mg/ml) are statistically better solvent compared to water for both alpha-glucosidase and alphaamylase inhibitor. Kaempferol 3-O-β-glucopyranoside or astragalin is present I S. palustris and highly possible to be the major compound responsible on S. palustris maltase inhibitory activity.

Item Type:	Thesis (Bachelor)
Uncontrolled Keywords:	S. Palustris ; Alpha-Glucosidase Inhibitors ; Alpha-Amylase Inhibitors ; Column Chromatography ; LC-MS
Subjects:	T Technology > TP Chemical technology > TP368 Food processing and manufacture
Divisions:	Faculty of Life Sciences and Technology > Department of Food Technology
Depositing User:	Adityatama Ratangga
Date Deposited:	19 May 2020 12:54
Last Modified:	19 May 2020 12:54
URI:	http://repository.sgu.ac.id/id/eprint/519

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