EYE DROP PRODUCT DEVELOPMENT FROM BUTTERFLY PEA EXTRACT

Alimin, Clarissa Eda and Susanto, Hery and Marpaung, Abdullah Muzi (2022) EYE DROP PRODUCT DEVELOPMENT FROM BUTTERFLY PEA EXTRACT. Bachelor thesis, Swiss German University.

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Abstract

Eye infections are prevalent among individuals and commonly treated with commercially available chemically synthesized eye drops. However, there is a growing interest in herbal medicine, with approximately 80% of the global population utilizing it. In line with this, the present study aims to develop herbal-based eye drops using butterfly pea as the main ingredient. Butterfly pea is recognized for its abundant anthocyanin content, which possesses potent therapeutic properties against eye infections. Ultrasound-Assisted Extraction, autoclave sterilization, disk diffusion test, and macrodilution were employed as key methodologies in this investigation. Results revealed that the double-flower variant of butterfly pea exhibited higher levels of anthocyanin content (138.842 mg/L) and total phenolic content (657.363 mg of GAE/gram extract). The addition of 2% L-Histidine effectively stabilized the anthocyanin compound. Autoclave sterilization demonstrated efficacy in ensuring extract sterility. In addition, the commercial products without herbal ingredients exhibited a larger inhibition zone of 12.3 mm, while the formulated herbal eye drops demonstrated significant inhibition of Staphylococcus aureus growth, with an inhibition zone diameter of 8.3 mm.

Item Type: Thesis (Bachelor)
Subjects: R Medicine > RS Pharmacy and materia medica > RS160 Plant extracts
Divisions: Faculty of Life Sciences and Technology > Department of Pharmaceutical Engineering
Depositing User: Mr Arinton Sinaga
Date Deposited: 12 Dec 2024 02:32
Last Modified: 12 Dec 2024 02:32
URI: http://repository.sgu.ac.id/id/eprint/2732

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