Verdiansin, Angeli and Audah, Kholis Abdurachim and Arsianti, Ade and Susanto, Hery (2022) VIABILITY OF LIPOSOMAL-NANOECAPSULATED AVICENNIA MARINA ROOTS ETHYL ACETATE EXTRACT AS POTENTIAL ANTICANCER DRUG. Bachelor thesis, Swiss German University.

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Abstract

Cancer id a group of diseases characterized by its rapid spread and growth. Currently available cancer treatments come with harmful side effects, prompting an interest in naturally-derived drugs as a possible alternative treatment. The Mangrove consists of a number of species and is found to have anticancer properties due to its phytochemical content. In this thesis work, Avicennia Marina roots is extracted with ethyl acetate and enclosed within Liposome to be studied as a potential Anticancer drug. The encapsulation of extract is expected to preserve its quality. The extract is found to contain Phenolics in a moderate amount (392.84 mg/g) and flavonoids in a large amount (2960.4 mg/g). The antioxidant activity of extract before and after encapsulation is found to be inactive (IC50 = 1351.82 +2.23 ppm and 1702.98 + 3.37 ppm, respectively). The encapsulation is calculated to be 73.86 + 0.02% efficient and encapsulated extract has a particle size of 436.27 nm, PI of 0.627, and zeta potential of -63.27 mV. The anticancer activity of both encapsulated and non-encapsulated extract against MCF-7, HeLa, and Hep G2 cells is categorized as active-highly active. The BLST method also proved that both encapsulated and non-encapsulated extracts are non-toxic towards normal cells (LC50>1000 ppm),

Item Type:	Thesis (Bachelor)
Subjects:	R Medicine > RS Pharmacy and materia medica R Medicine > RS Pharmacy and materia medica > RS160 Plant extracts
Divisions:	Faculty of Life Sciences and Technology > Department of Biomedical Engineering
Depositing User:	Mr Arinton Sinaga
Date Deposited:	10 Dec 2024 04:02
Last Modified:	10 Dec 2024 04:02
URI:	http://repository.sgu.ac.id/id/eprint/2669

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